Circulomics has published a paper detailing a simple method for high efficiency and low bias microRNA capture. This paper, entitled "Elimination of Ligation Dependent Artifacts in T4 RNA Ligase to Achieve High Efficiency and Low Bias microRNA Capture," was published in the journal PLOS ONE in conjunction with Dr. Tza-Huei Wang of Johns Hopkins University.
Adapter ligation is the first step in wide array of microRNA analysis methods. Low bias capture methods are essential in preventing distortion of microRNA expression profiles. Circulomics has developed a simple method for microRNA capture that does not require the use of large adapter pools and forms the foundation for Ligo-miR.