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Small Technologies

Going to PAG? Visit Booth 203 and Our Poster to Learn More About Our New Tissue Kit.
Hate Short Reads? Eliminate Them! Short Read Eliminator Kits Are Here.
Want Long Reads?Want the Highest Quality, HMW DNA? Have a Challenging Sample? Nanobind Big DNA Kits Available Now.
Big Advances

News and Publications

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Circulomics has been featured in:

 
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Oct 2019

High Throughput HMW DNA Extraction from Human Tissues

ASHG 2019

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Mar 2019

HMW DNA Extraction and Size Selection

 / PacBio Microbial Multiplexing

ABRF 2019

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Jan 2019

Rapid HMW DNA Extraction from Plant, Insect, Cell, and Tissue Samples

PAG XXVII

June 2018

Multiplexed Microbial Sequencing in Collaboration with PacBio

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Aug 2019

Sample Prep Workshop

Nanobind HMW DNA Extraction

Genome 10K Conference

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Feb 2019

Rapid Extraction and Size Selection of HMW DNA for Long-Read Sequencing

AGBT 2019

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October 2018

Nanobind Sample Prep for Long-Read Sequencing and Optical Mapping.

ASHG 2018

June 2018

Circulomics Wins Best Innovative Tech Company Award

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May 2019

HMW DNA Extraction and Size Selection for Long Read Sequencing

NHGRI Advanced Genomics

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Jan 2019

DNA Extraction Remains Bottleneck for Long-Read Techs but Solutions Emerge

GenomeWeb

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Sept 2018

Sample Prep Workshop

Nanobind HMW DNA Extraction

Genome 10K Conference

April 2018

HMW DNA Extraction from Recalcitrant Plant Species for 3rd Gen Sequencing

Protocol Exchange

 
Micro and Nanoscale Silica
Each non-porous Nanobind disk is covered with a high density of micro- and nanostructured silica that can bind vast amounts of DNA and protect it from shearing. A single disk is used per extraction and can be processed either manually or automated using standard robotic instruments.
Rapid Bind, Wash, and Elute
HMW DNA extraction can be performed using a simple bind, wash, and elute protocol that is automation compatible.
HMW DNA (50 - 300+kb)
Nanobind Big DNA Kits can be used to obtain HMW DNA (50 - 300+ kb) from nearly all sample types. All samples have been validated by long-read sequencing on PacBio and ONT.
UHMW DNA (50 kb - 1+ Mb)
Nanobind's High Molecular Weight (HMW) process provides DNA from 50 kb - 300 kb while the Ultra High Molecular Weight (UHMW) process provides DNA from 50 kb - 5.7 Mb+.
Ultra Long Reads on ONT
Nanobind UHMW DNA can be used to obtain megabase length reads on Oxford Nanopore and for optical mapping.
Cells, Bacteria, and Blood
The Nanobind CBB Big DNA Kit can be used to extract HMW and UHMW DNA from cultured cells, cultured bacteria, and whole blood.
Plants
The Nanobind Plant Nuclei Big DNA Kit can be used to extract HMW DNA from a wide array of plants from pine needles and cotton to lavender and grapevines.
Tissues
The Nanbind Tissue Big DNA Kit can be used to extract HMW DNA from human, mouse, monkey, pig, fish, crab, snail, slug, bird, and select insect samples.
ONT Nanopore Sequencing
All Nanobind kits are designed to generate consistent read lengths and throughputs across diverse sample types from cells to plants and tissues.
PacBio SMRT Sequencing
All Nanobind kits are designed to generate consistent read lengths and throughputs across diverse sample types from cells to plants and tissues.
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3 Depletion Cutoffs
Choose your SRE kit based on the quality of your input DNA from fragmented DNA or PCR amplicons to high quality HMW DNA.
SRE XS Kit - Up to 10 kb
Short DNA depletion begins at 10 kb and increases in effectiveness as the DNA gets shorter.
SRE Kit - Up to 25 kb
Short DNA depletion begins at 25 kb and increases in effectiveness as the DNA gets shorter.
SRE XL Kit - Up to 40 kb
Short DNA depletion begins at 40 kb and increases in effectiveness as the DNA gets shorter.
Simple Precipitation Process
Process up to 20 samples in 1 hour with just a centrifuge.
Enhance Read Length
The read length enhancement scales with more aggressive depletion of short DNA.
Nanobind Blood DNA SRE XL
SRE XL begins depleting short DNA at 40 kb, leading to a 14 kb enhancement in read length N50.
Puregene Cell DNA SRE
SRE is compatible with DNA extracted using any technology.
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PicoSep Single Molecule System
Each PicoSep system consists of a single molecule detection module (shown), electronics module, and flow control module. The entire system is USB-controlled by laptop.
PicoSep Separation Capillary
Separation is performed by injecting a sample plug into a buffer-filled microcapillary and driving with pressure. Single molecule sensitivity enables analysis to be performed using only 5 pL of sample and <20 DNA molecules.
PicoSep Single Molecule DNA Sizing
DNA molecules are individually detected (bottom) and counted to form chromatograms (top). Each vertical spike is a single DNA molecule. Larger molecules elute first.
PicoSep RNA Integrity Analysis
Single molecule sensitivity enables detection of minute amounts of RNA degradation and more accurate quantification of RNA integrity by direct counting of degraded molecules.
PicoSep High MW DNA Sizing
PicoSep can accurately size and quantify high molecular weight DNA (100 kb+) in <2 hours. No electrophoresis method offers this speed, sizing resolution, or quantification capability.
PicoSep Single Molecule Conformation
Individual single molecule spikes can be analyzed to determine molecular information such as size, packing density, and conformation. This trace shows a large DNA molecule randomly folded at the leading front and stretched out at the rear.
Show More
 
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Micro and Nanoscale Silica

Each non-porous Nanobind disk is covered with a high density of micro- and nanostructured silica that can bind vast amounts of DNA and protect it from shearing. A single disk is used per extraction and can be processed either manually or automated using standard robotic instruments.