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Small Technologies

Have a Tough Animal to Sequence? The Nanobind Tissue Big DNA Kit is Here!
Going to PAG? Visit Booth 203 and Our Poster to Learn More About Our New Tissue Kit.Also, find use at Oxford Nanopore NCM in NY.
Want Long Reads?Use Nanobind Big DNA Kits to Extract the Highest Quality HMW DNA and Short Read Eliminator to Deplete Small DNA.
Big Advances
 

News, Events, & Publications

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See Circulomics at:

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Feb 2020

Invited Talk - HMW DNA Extraction Long-Read Sequencing

ABRF 2020

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Dec 2019

Delegates

ONT NCM

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May 2019

HMW DNA Extraction and Size Selection for Long Read Sequencing

NHGRI Advanced Genomics

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Feb 2019

Rapid Extraction and Size Selection of HMW DNA for Long-Read Sequencing

AGBT 2019

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Feb 2020

HMW DNA from Clinical Tissues /

Automated HMW DNA Extraction

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Oct 2019

High Throughput HMW DNA Extraction from Human Tissues

ASHG 2019

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Mar 2019

HMW DNA Extraction and Size Selection

 / PacBio Microbial Multiplexing

ABRF 2019

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Jan 2019

DNA Extraction Remains Bottleneck for Long-Read Techs but Solutions Emerge

GenomeWeb

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Jan 2020

Booth #203

HMW DNA from Animals and Plants

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Aug 2019

Sample Prep Workshop

Nanobind HMW DNA Extraction

Genome 10K Conference

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Jan 2019

Rapid HMW DNA Extraction from Plant, Insect, Cell, and Tissue Samples

PAG XXVII

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October 2018

Nanobind Sample Prep for Long-Read Sequencing and Optical Mapping.

ASHG 2018

 
Micro and Nanoscale Silica
Each non-porous Nanobind disk is covered with a high density of micro- and nanostructured silica that can bind vast amounts of DNA and protect it from shearing. A single disk is used per extraction and can be processed either manually or automated using standard robotic instruments.
Rapid Bind, Wash, and Elute
HMW DNA extraction can be performed using a simple bind, wash, and elute protocol that is automation compatible.
HMW DNA (50 - 300+kb)
Nanobind Big DNA Kits can be used to obtain HMW DNA (50 - 300+ kb) from nearly all sample types. All samples have been validated by long-read sequencing on PacBio and ONT.
UHMW DNA (50 kb - 1+ Mb)
Nanobind's High Molecular Weight (HMW) process provides DNA from 50 kb - 300 kb while the Ultra High Molecular Weight (UHMW) process provides DNA from 50 kb - 5.7 Mb+.
Ultra Long Reads on ONT
Nanobind UHMW DNA can be used to obtain megabase length reads on Oxford Nanopore and for optical mapping.
Cells, Bacteria, and Blood
The Nanobind CBB Big DNA Kit can be used to extract HMW and UHMW DNA from cultured cells, cultured bacteria, and whole blood.
Plants
The Nanobind Plant Nuclei Big DNA Kit can be used to extract HMW DNA from a wide array of plants from pine needles and cotton to lavender and grapevines.
Tissues
The Nanbind Tissue Big DNA Kit can be used to extract HMW DNA from human, mouse, monkey, pig, fish, crab, snail, slug, bird, and select insect samples.
ONT Sequencing
PacBio Sequencing
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3 Depletion Cutoffs
Choose your SRE kit based on the quality of your input DNA from fragmented DNA or PCR amplicons to high quality HMW DNA.
SRE XS Kit - Up to 10 kb
Short DNA depletion begins at 10 kb and increases in effectiveness as the DNA gets shorter.
SRE Kit - Up to 25 kb
Short DNA depletion begins at 25 kb and increases in effectiveness as the DNA gets shorter.
SRE XL Kit - Up to 40 kb
Short DNA depletion begins at 40 kb and increases in effectiveness as the DNA gets shorter.
Simple Precipitation Process
Process up to 20 samples in 1 hour with just a centrifuge.
Enhance Read Length
The read length enhancement scales with more aggressive depletion of short DNA.
Nanobind Blood DNA SRE XL
SRE XL begins depleting short DNA at 40 kb, leading to a 14 kb enhancement in read length N50.
Puregene Cell DNA SRE
SRE is compatible with DNA extracted using any technology.
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PicoSep Single Molecule System
Each PicoSep system consists of a single molecule detection module (shown), electronics module, and flow control module. The entire system is USB-controlled by laptop.
PicoSep Separation Capillary
Separation is performed by injecting a sample plug into a buffer-filled microcapillary and driving with pressure. Single molecule sensitivity enables analysis to be performed using only 5 pL of sample and <20 DNA molecules.
PicoSep Single Molecule DNA Sizing
DNA molecules are individually detected (bottom) and counted to form chromatograms (top). Each vertical spike is a single DNA molecule. Larger molecules elute first.
PicoSep RNA Integrity Analysis
Single molecule sensitivity enables detection of minute amounts of RNA degradation and more accurate quantification of RNA integrity by direct counting of degraded molecules.
PicoSep High MW DNA Sizing
PicoSep can accurately size and quantify high molecular weight DNA (100 kb+) in <2 hours. No electrophoresis method offers this speed, sizing resolution, or quantification capability.
PicoSep Single Molecule Conformation
Individual single molecule spikes can be analyzed to determine molecular information such as size, packing density, and conformation. This trace shows a large DNA molecule randomly folded at the leading front and stretched out at the rear.
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Micro and Nanoscale Silica

Each non-porous Nanobind disk is covered with a high density of micro- and nanostructured silica that can bind vast amounts of DNA and protect it from shearing. A single disk is used per extraction and can be processed either manually or automated using standard robotic instruments.