News and Views

04/10/2014 Circulomics has published a paper detailing a simple method for high efficiency and low bias microRNA capture. This paper, entitled "Elimination of Ligation Dependent Artifacts in T4 RNA Ligase to Achieve High Efficiency and Low Bias microRNA Capture," was published in the journal PLOS ONE in conjunction with Dr. Tza-Huei Wang of Johns Hopkins University.

Adapter ligation is the first step in wide array of microRNA analysis methods. Low bias capture methods are essential in preventing distortion of microRNA expression profiles. Circulomics has developed a simple method for microRNA capture that does not require the use of large adapter pools and forms the foundation for Ligo-miR.

miRNA capture

04/04/2014 The National Institute of General Medical Sciences (NIGMS) has awarded Circulomics a new Phase I SBIR to develop a novel nanomaterial for DNA and RNA extraction. This material called Nanobind can extract over 150 micrograms of DNA from a single extraction within a 1.5 mL microcentrifuge tube. This represents >15 times greater binding capacity than conventional spin columns or magnetic beads. This is possible due to Nanobind's hierarchical structure of microscale folds topped by nanoscale wrinkles which creates an extraordinarily high surface area that imparts little to no shear force to the DNA. Extracted DNA routinely exceeds 48 kb in length, with purity and integrity that rivals phenol-chloroform and a process that is even simpler than spin column. Nanobind is fabricated using a simple and elegant process based on an inexpensive thermoplastic film.

This grant will enable Circulomics to develop a broad portfolio of products for DNA and RNA extraction from cells, tissues, blood and other samples that achieves an unmatched combination of yield, purity, and integrity.

NIHNIGMS

02/01/2014 Meet two of the members of our technical team, Dr. Jeffrey Burke and Dr. Duncan Kilburn. Dr. Burke is our resident microfluidics expert and leads the development the PicoSep single molecule DNA sizing platform. He is well-versed in the chromatographic, electrokinetic, and microfluidic molecular separation principles that underlie PicoSep. Dr. Burke is also well known for his prize winning chili and his locally famous cannolis. Dr. Kilburn is a physicist leading a dual life as an RNA biologist. He leads the development of the Ligo-miR microRNA assay platform and is an expert in the molecular folding of RNA and polymers. As a true Englishman, Dr. Kilburn is known for his affection for afternoon tea.

Dr. Jeffrey Burke J Burke Dr. Duncan KilburnD Kilburn

06/24/2013 A Baltimore Sun article covers the launch of JHU's FastForward Accelerator and coincides with the official Opening Celebration held on June 27, 2013. In the article, Circulomics CEO Dr. Kelvin Liu discusses the changing attitudes towards entrepreneurship that are developing within the JHU ecosystem.

Dr. Kelvin Liu Balt Sun - K Liu Baltimore Sun Logo

03/01/2013 Circulomics has brought on Tom Bishop as a member of the Advisory Board. He has over 15 years of experience marketing and launching biotech products at companies such as Exiqon, Microlytic, Ambion, and Invitrogen. He is currently Chief Business Officer at Emerald Biostructures. He brings substantial expertise and insight into the microRNA product space through his time as Site Leader and General Manager of Exiqon NA. Mr. Bishop will help guide Circulomics' product launch, sales, marketing, manufacturing, and distribution strategies.

Tom Bishop Tom Bishop

01/10/2013 Circulomics enters as the second company accepted into Johns Hopkins' newly established FastForward Technology Accelerator. FastForward is sponsored by the Johns Hopkins University Whiting School of Engineering to promote the commercialization of research technologies developed by its faculty, students, and affiliates. It is JHU's first technology accelerator. As part of the program, Circulomics will receive dedicated office and lab space in the Stieff Silver building, business development and IP guidance from the Homewood Intellectual Property and Commercialization Office, and access to newly established core facilities.

FastForward LogoJHU Logo

12/10/2012 Circulomics issues a press release to announce SBIR awards. These awards, totaling $800k over 2 years, will drive the development of the Ligo-miR microRNA Assay Platform and the PicoSep Single Molecule Analysis Instrument. According to Circulomics CEO Dr. Kelvin Liu, "We see a critical market need for new molecular assays that are not only powerful in nature but also cost effective and easy to use. Winning two such highly competitive awards validates both the novelty of our technologies as well as the new thinking with which we are approaching the market."

Circulomics receives coverage on Genomeweb, peHUB, Yahoo!, citybizlist, and Technically Baltimore.

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09/24/2012 Circulomics has been awarded a 2nd $400k, 2 year Phase I SBIR grant by the National Institutes of Health (NIH) / National Institute of General Medical Sciences (NIGMS). This grant was awarded to develop Ligo-miR microRNA profiling technology. Ligo-miR enables highly quantitative and sensitive multiplex analysis of microRNA expression in only a few simple steps. This highly competitive award was funded as part of NIH's SHIFT initiative to foster the translation of scientific discoveries from the lab to the marketplace.

NIHNIGMS

09/17/2012 Circulomics has been awarded a $400k, 2 year Phase I SBIR grant by the National Institutes of Health (NIH) / National Institute of General Medical Sciences (NIGMS) to develop PicoSep single molecule DNA sizing and separation technology. PicoSep is among the most sensitive DNA sizing platforms published to date and allows accurate quantification of DNA from as little as a few picoliters of sample. PicoSep will form the basis of Circulomics' most advanced biomarker analysis platforms. This highly competitive award was funded as part of NIH's SHIFT initiative to foster the translation of scientific discoveries from the lab to the marketplace.

NIHNIGMS

08/30/2012 Circulomics receives a $75k award from Maryland Technology Development Corporation's (TEDCO)  Maryland Technology Transfer and Commercialization Fund (MTTCF)  to commercialize Ligo-miR EZ microRNA assay technology for cancer research. TEDCO was established by the State of Maryland to facilitate early stage companies in the commercial translation of technology from MD universities and research institutes. Circulomics was selected as one of 16 companies receiving a total of $1,170,885 in funding.

TEDCO

07/08/2012  Dr. Kelvin Liu, CEO and Founder, presents the PicoSep single molecule DNA sizing and separation platform at the 2012 ASME ICNMM Conference in Puerto Rico.

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04/19/2011  Single Molecule Free Solution Hydrodynamic Separation, which is the basis of the PicoSep platform, is published in the Journal of the American Chemical Society.

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