Sample Prep Scientist


We’re looking for smart, dedicated, and creative people to join our team. As in any startup environment, candidates who are flexible enough to fill many roles can be expected to grow quickly within the company and play a large part in shaping its future. Today, you may be working at the lab bench while tomorrow, you may be writing a patent, and the day after, you may be meeting with customers.

Sample Preparation Scientist (Posted 11/2015)

Circulomics' Nanobind technology uses a novel thermoplastic, silica nanomaterial to perform rapid and high quality DNA/RNA extraction from a comprehensive array of sample types. Nanobind represents a fundamentally different approach to silica-based DNA extraction than existing column and magnetic particle technologies. Nanobind's high surface area and low shear format make it perfectly suited to routine DNA/RNA extraction as well as challenging new applications including microvolume extractions, long-read sequencing, and clinical diagnostics.

The applicant's primary responsibility will be the development of new extraction chemistries and the expansion of Nanobind technology into new areas in sample preparation. The applicant will also be responsible for the demonstration of the extracted DNA and RNA in ultimate applications including PCR, RT-PCR, sequencing, cloning, etc. The ideal candidate would welcome broad exposure to all aspects of bringing a new nanotechnology to market.

Specific responsibilities include:

  • Development, fabrication, and characterization of Nanobind material and novel variants
  • Development and optimization of new extraction chemistries and protocols
  • Validation of extraction chemistries across diverse sample types and extraction conditions
  • Application development using PCR, RT-PCR, sequencing, cloning, etc
  • Characterization of extracted nucleic acids using spectroscopy, gel electrophoresis, capillary electrophoresis, restriction digests, qPCR, and qRT-PCR

B.S., M.S., or PhD in Engineering fields, Biological sciences, or Chemical sciences

Desired skills:

  • Significant expertise in sample preparation techniques incorporating spin columns, magnetic particles, and precipitation
  • Experience handling and analyzing clinical samples including blood, tissue, FFPE samples, bodily fluids, etc
  • Experience with molecular biology techniques including UV and fluorescence spectroscopy, qPCR and qRT-PCR, agarose and pulsed field gel electrophoresis, and cloning
  • Experience in sequencing and library preparation
  • Experience in genetics and epigenetics analysis
  • Expertise in silica surface chemistry is a plus but not required
  • Cell culture experience is a plus but not required
  • Experience with laboratory automation equipment is a plus but not required
  • Demonstrated experience in conceptualizing, leading, and performing independent research
  • Applicants don't need to have all the desired skills but should demonstrate eagerness and ability to learn new techniques as necessary
  • Anything else to help the company grow and expand!

Immediate start date. Full benefits apply.

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